Fowler, A. Bellin et al. Darbra, A. Ginebreda, P. Hansen, S. Sabater, L. Galbiati et al. Back Matter Pages About this book Introduction The Ebro is a typical Mediterranean river characterized by seasonal low flows and extreme flush effects, with important agricultural and industrial activity that has caused heavy contamination problems.
While effective, Effect of juvenile hormone and serotonin 5- HT on mixis induction of the rotifer Brachionus plicatilis Muller. Juvenile hormone JH and serotonin 5- HT were previously shown to enhance mictic sexual female production of the rotifer Brachionus plicatilis in batch cultures. To explore the basis of these effects, experiments were conducted on isolated individuals. When food level was reduced to 7x10 5 cellsml -1 , however, 5- HT -treated rotifers produced significantly P HT -treated rotifers did not differ from that of the control with or without free ammonia, but the intrinsic rate of natural increase r of 5- HT -treated rotifers at 3.
These results show that juvenile hormone increases mictic female production under optimum and sub-optimum food levels, whereas 5- HT increases both mictic female production at low food level and population growth rate at high free ammonia concentrations.
These compounds could be used to manage rotifer cultures and probe the mechanisms controlling the rotifer life cycle as it switches to mictic reproduction. Hormone therapy in postmenopausal women affects hemispheric asymmetries in fine motor coordination. Evidence exists that the functional differences between the left and right cerebral hemispheres are affected by age.
One prominent hypothesis proposes that frontal activity during cognitive task performance tends to be less lateralized in older than in younger adults, a pattern that has also been reported for motor functioning.
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Moreover, functional cerebral asymmetries FCAs have been shown to be affected by sex hormonal manipulations via hormone therapy HT in older women. Here, we investigate whether FCAs in fine motor coordination, as reflected by manual asymmetries MAs , are susceptible to HT in older women.
Saliva levels of free estradiol and progesterone P were analyzed using chemiluminescence assays. MAs were measured with a finger tapping paradigm consisting of two different tapping conditions. As expected, postmenopausal controls without HT showed reduced MAs in simple repetitive finger tapping.
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In a more demanding sequential condition involving four fingers, however, they revealed enhanced MAs in favour of the dominant hand. This finding suggests an insufficient recruitment of critical motor brain areas especially when the nondominant hand is used , probably as a result of age-related changes in corticocortical connectivity between motor areas.
In contrast, both HT groups revealed reduced MAs in sequential finger tapping but an asymmetrical tapping performance related to estradiol levels in simple finger tapping. A similar pattern has previously been found in younger participants. The results suggest that, HT , and E exposure in particular, exerts positive effects on the motor system thereby counteracting an age-related reorganization.
Copyright Elsevier Inc. All rights reserved. Hormone Therapy in Clinical Equine Practice. A wide variety of hormone therapies are used in clinical practice in the reproductive management of horses. The goal of this article is to review therapeutic options for a variety of clinical indications. Risks and benefits of hormone therapy : has medical dogma now been overturned?
In an integrated overview of the benefits and risks of menopausal hormone therapy HT , the Women's Health Initiative WHI investigators have claimed that their 'findings … do not support use of this therapy for chronic disease prevention'. In an accompanying editorial, it was claimed that 'the WHI overturned medical dogma regarding menopausal [ HT ]'. To evaluate those claims. Epidemiological criteria of causation were applied to the evidence. A 'global index' purporting to summarize the overall benefit versus the risk of HT was not valid, and it was biased. Under 'worst case' and 'best case' assumptions, the changes in the incidence of the outcomes attributable to HT were minor.
Over-interpretation and misrepresentation of the WHI findings have damaged the health and well-being of menopausal women by convincing them and their health professionals that the risks of HT outweigh the benefits. Objective To test the added value of Calcium and vitamin D CaD for fracture prevention among women taking postmenopausal hormone therapy HT. A total of 16, women were in both arms.http://ugmek.ru/includes/ly-chloroquine-diphosphate.php
The predefined outcomes were adjudicated hip fractures and measured bone mineral density. CaD supplementation enhanced the anti-fracture effect of the HT at all levels of personal calcium intake. Conclusions Postmenopausal women at normal risk of hip fracture on HT , supplementation with CaD significantly reduced incident hip fracture beyond HT alone; at all levels of personal baseline total calcium intake. Hormone therapy use and physical quality of life in postmenopausal women with multiple sclerosis.
To determine the association between hormone therapy HT and physical quality of life QOL in postmenopausal women with multiple sclerosis MS. We included female participants from the prospective Nurses' Health Study, with a diagnosis of definite or probable MS, who had completed a physical functioning assessment PF10; subscale of the Item Short-Form Health Survey QOL survey at a time point between 3 and 10 years after their final menstrual period early postmenopause.
We used a linear regression model adjusting for age, MS duration, menopause type and duration, and further for additional covariates only ancestry was significant. Among 95 participants meeting all inclusion criteria at their first postmenopausal assessment, 61 reported HT use and 34 reported none. Further studies are necessary to investigate causality. Little is known regarding specific populations of women who may derive benefit from HT.
Women with heightened risk for AD aged , all of whom were taking HT for at least 1 year and most of whom initiated HT close to menopause onset, underwent cognitive assessment followed by randomization to continue or discontinue HT. Assessments were repeated at 2 years after randomization. Women who continued HT performed better on cognitive domains composed of measures of verbal memory and combined attention, working memory, and processing speed measures.
An interaction was also found with HT randomization and family history of AD in a first-degree relative. All female offspring of patients with AD declined in verbal memory; however, women who continued HT declined less than women who discontinued HT. Women without a first-degree relative with AD showed verbal memory improvement likely because of practice effects with continuance and declined with discontinuance of HT. Continuation of HT use appears to protect cognition in women with heightened risk for AD when initiated close to menopause onset.
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Published by Elsevier Inc. Women with heightened risk for AD aged , all of whom were taking HT for at least one year, most of whom initiated HT close to menopause onset, underwent cognitive assessment followed by randomization to continue or discontinue HT. Assessments were repeated at two years after randomization. Women who continued HT performed better on cognitive domains composed of measures of verbal memory, and combined attention, working memory, and processing speed measures. An interaction was also found with HT randomization and family history of AD in a first degree relative.
All women offspring of patients with AD declined in verbal memory however, women who continued HT declined less than women who discontinued HT.
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Women without a first-degree relative with AD showed verbal memory improvement likely due to practice effects with continuance and declined with discontinuance of HT. The aim of this study was to determine the effect of oral hormone therapy HT on oxidative stress OS in postmenopausal women with metabolic syndrome MetS. A randomized, double blind, placebo-controlled trial was carried out. We measured plasma lipoperoxides, erythrocyte superoxide dismutase and glutathione peroxidase, total plasma antioxidant status and uric acid, as OS markers.
Alternative cut-off values of each parameter were defined and a stress score SS ranging from 0 to 7 was used as total OS. Participants were seen at baseline, 3 and 6 months. In placebo groups there was no change. Perspectives on counseling patients about menopausal hormone therapy : strategies in a complex data environment.
This narrative review strives to give healthcare providers HCPs who care for menopausal women better tools and skills to initiate discussions with women about menopause and hormone therapy HT , communicate complex concepts and data, and promote shared decision-making. We review relevant studies on HT , barriers to treatment of menopausal symptoms, and effective communication strategies. We also provide recommendations for communicating with patients about HT based on the medical literature and our own professional experience.
Both patient and HCP-related barriers can prevent women from accessing treatment for bothersome symptoms of menopause. The benefits and risks vary with patient age and time since menopause, duration of use, inclusion of a progestin, and patient medical history. Women may also have fears about potential side effects of HT and feel unable to make informed choices.
Strategies for effective patient communication and shared decision-making include use of open-ended questions to elicit patient's concerns and preferences, reflecting back to the patient what the HCP heard, presenting evidence about benefits and risks in language the patient can understand, keeping risks in perspective eg, provide absolute, and also relative risks without minimizing them, and making conscious efforts to minimize potential bias.
Necessary components for achieving high-quality, shared decisions about HT involve a combination of medical evidence, communication skills, and recognition of patient goals and concerns. Use of such strategies can enhance women's satisfaction with care. Hormone therapy for radiorecurrent prostate cancer. The management of patients who relapse after radical radiotherapy is a challenging problem for the multidisciplinary team. This group of men may have been considered ineligible or chosen not to be treated with an initial surgical approach as a result of high-risk features or significant comorbid conditions.
It is important not to miss the opportunity for definitive local salvage therapies at this stage, and eligible patients should undergo careful restaging to determine their suitability for these approaches.